Supplementation with nanobubble water alleviates obesity-associated markers through modulation of gut microbiota in high-fat diet fed mice

Autor: Zitao Guo, Bo Hu, Hanxiao Wang, Lingquan Kong, Hanlin Han, Kejuan Li, Shuang Sun, Zhongfang Lei, Kazuya Shimizu, Zhenya Zhang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Functional Foods, Vol 67, Iss , Pp 103820- (2020)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2020.103820
Popis: This study aims to investigate the effects of nanobubble water (NBW) on the process of obesity in mice under high-fat diet (HFD). In the experimental groups, HFD feeding mice were supplemented with nitrogen NBW (HFD-N2) or hydrogen NBW (HFD-H2), while the mice fed with standard diet (SD-C) or HFD (HFD-C) supplementation with deionized water were used as control groups. After ten weeks, the concentrations of total cholesterol, alanine aminotransferase and lipopolysaccharide in the mice serum of the HFD-N2 group were significantly lower than those in the HFD-C group. 16S rRNA gene sequencing analysis of the community structures of fecal flora showed that supplementation with N2-NBW to the HFD fed mice could decrease the ratio of Firmicutes to Bacteroidetes. In conclusion, these results demonstrate that supplementation with N2-NBW potentially alleviates the development of obesity in HFD fed mice.
Databáze: Directory of Open Access Journals