Ambient air pollutants, diabetes and risk of newly diagnosed drug-resistant tuberculosis

Autor: Wan-mei Song, Yi Liu, Qian-yun Zhang, Si-qi Liu, Ting-ting Xu, Shi-jin Li, Qi-qi An, Jin-yue Liu, Ning-ning Tao, Yao Liu, Chun-Bao Yu, Cui-xiang Yu, Yi-fan Li, Huai-chen Li
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Ecotoxicology and Environmental Safety, Vol 219, Iss , Pp 112352- (2021)
Druh dokumentu: article
ISSN: 0147-6513
DOI: 10.1016/j.ecoenv.2021.112352
Popis: Background: Drug-resistant tuberculosis (DR-TB), diabetes and exposure to air pollution are thought to be important threat to human health, but no studies have explored the effects of ambient air pollutants on DR-TB when adjusting diabetes status so far. Methods: We performed a study among 3759 newly diagnosed TB cases with drug-susceptibility testing results, diabetes status, and individual air pollution data in Shandong from 2015 to 2019. Generalized linear mixed models (GLMM) including three models (Model 1: without covariates, Model 2: adjusted by diabetes status only, Model 3: with all covariates) were applied. Results: Of 3759 TB patients enrolled, 716 (19.05%) were DR-TB, and 333 (8.86%) had diabetes. High exposure to O3 was associated with an increased risk of RFP-resistance (Model 2 or 3: odds ratio (OR) = 1.008, 95% confidence intervals (CI): 1.002–1.014), ethambutol-resistance (Model 3: OR = 1.015, 95%CI: 1.004–1.027) and any rifampicin+streptomycin resistance (Model 1,2,3: OR = 1.01, 95%CI: 1.002–1.018) at 90 days. In contrast, NO2 was associated with a reduced risk of DR-TB (Model 3: OR = 0.99, 95%CI: 0.981–0.999) and multidrug-resistant TB (MDR-TB) (Model 3: OR = 0.977, 95%CI: 0.96–0.994) at 360 days. Additionally, SO2 (Model 1, 2, 3: OR = 0.987, 95%CI: 0.977–0.998) showed a protective effect on MDR-TB at 90 days. PM2.5 (90 days, Model 2: OR = 0.991, 95%CI: 0.983–0.999), PM10 (360 days, Model 2: OR = 0.992, 95%CI: 0.985–0.999) had protective effects on any RFP+SM resistance. Conclusions: O3 contributed to an elevated risk of TB resistance but PM2.5, PM10, SO2, NO2 showed an inverse effect. Air pollutants may affect the development of drug resistance among TB cases by adjusting the status of diabetes.
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