| Autor: |
Ciaran J. McCoy, Louise E. Atkinson, Mostafa Zamanian, Paul McVeigh, Tim A. Day, Michael J. Kimber, Nikki J. Marks, Aaron G. Maule, Angela Mousley |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
EuPA Open Proteomics, Vol 3, Iss C, Pp 262-272 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2212-9685 |
| DOI: |
10.1016/j.euprot.2014.04.002 |
| Popis: |
FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flp and flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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