| Autor: |
H. Sharma, MSc, PhD, V.Y. Vishnu, MD, DM, N. Kumar, MD, V. Sreenivas, MSc, PhD, M.R. Rajeswari, MSc, PhD, R. Bhatia, MD, DM, R. Sharma, BPT, M.V. Padma Srivastava, MD, DM |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Archives of Rehabilitation Research and Clinical Translation, Vol 2, Iss 1, Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1095 |
| DOI: |
10.1016/j.arrct.2020.100039 |
| Popis: |
Objective: To investigate the role of low-frequency repetitive transcranial magnetic stimulation (rTMS) along with conventional physiotherapy in the functional recovery of patients with subacute ischemic stroke. Design: Double-blind, parallel group, randomized controlled trial. Setting: The outpatient department of a tertiary hospital participants: first ever ischemic stroke patients (N=96) in the previous 15 days were recruited and were randomized after a run-in period of 75±7 days into real rTMS (n=47) and sham rTMS (n=49) groups. Intervention: Conventional physical therapy was given to both the groups for 90±7 days postrecruitment. Total 10 sessions of low-frequency rTMS on contralesional premotor cortex was administered to real rTMS group (n=47) over a period of 2 weeks followed by physiotherapy regime for 45-50 minutes. Main Outcome Measures: The primary efficacy outcomes were change in modified Barthel Index (mBI) score (pre- to postscore) and proportion of participants with mBI score more than 90, measured at 90±7 days postrecruitment. The secondary outcomes were change in Fugl-Meyer Assessment–upper extremity, Fugl-Meyer Assessment–lower extremity, Hamilton Depression Scale, modified Rankin Scale, and National Institute of Health and Stroke Scale (pre- to post-rTMS) scores at 90±7 days post recruitment. Results: Modified intention to treat analysis showed a significant increase in the mBI score from pre- to post-rTMS in real rTMS group (4.96±4.06) versus sham rTMS group (2.65±3.25). There was no significant difference in proportion of patients with mBI>90 (55% vs 59%; P=.86) at 3 months between the groups. Conclusion: In patients with subacute ischemic stroke, 1-Hz low-frequency rTMS on contralesional premotor cortex along with conventional physical therapy resulted in significant change in mBI score. Keywords: Rehabilitation, Stroke, Transcranial magnetic stimulation |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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