Interactions of bioactive substances in herbal medicinal products with other pharmacotherapeutics
| Autor: | E. V. Shikh, V. M. Bulaev, O. A. Demidova, E. A. Sokova |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: |
фармакокинетическое взаимодействие
фармакодинамическое взаимодействие лекарственный растительный препарат нежелательные реакции изоферменты цитохрома p450 p-гликопротеин pharmacokinetic interaction pharmacodynamic interaction herbal medicinal product adverse drug reactions isoenzymes of cytochrome p450 p-glycoprotein Medicine (General) R5-920 |
| Zdroj: | Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 4, Pp 48-52 (2018) |
| Druh dokumentu: | article |
| ISSN: | 3034-3062 3034-3453 |
| Popis: | We have conducted an analysis of literature data on results of clinical trials suggesting that bioactive substances in some herbal medicinal preparations influence the efficacy and safety of medicines comprising various pharmacological classes if used concomitantly. Types of interactions between bioactive substances as a part of herbal medicines and chemically synthesized drugs have been discussed. It has been shown that in the case of concomitant use herbal medicinal products influence the pharmacodynamics of chemically synthesized drugs. This can either result in better safety and efficacy, or in adverse reactions. It is proved to be necessary to unify safety sections of patient information leaflets for herbal medicinal products approved in Russia for human use. |
| Databáze: | Directory of Open Access Journals |
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