New seco-anthraquinone glucoside from the roots of Rumex crispus

Autor: Yong-Xiang Li, Na Li, Jing-Juan Li, Man Zhang, Hong-Tao Zhu, Dong Wang, Ying-Jun Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 12, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-022-00350-3
Popis: Abstract A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napthalenones A-C (2–4), were isolated from the roots of Rumex crispus L., along with 10 known anthraquinones (6–14) and naphthalenone (5). Their structures were fully determined by extensive spectroscopic analyses, including ECD, and X-ray crystallography in case of compound 5, whose absolute configuration was determined for the first time. The isolates 1, 6–14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi, e.g., Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum. Most of the isolates showed weak anti-fungal and anti-inflammatory activity. Only compound 9 exhibited obvious anti-fungal activity against E. floccosum (MIC50 = 2.467 ± 0.03 μM) and M. gypseum (MIC50 = 4.673 ± 0.077 μM), while the MIC50 values of the positive control terbinafine were 1.287 ± 0.012 and 0.077 ± 0.00258 μM, respectively. The results indicated that simple emodin type anthraquinone is more potential against skin fungi than its oxyglucosyl, C-glucosyl and glycosylated seco analogues. Graphical Abstract
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