| Autor: |
Bruce Gale, Dolly J. Holt, Randon Michael Burr, Nathan Gooch, Balamurali Ambati |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Biomaterials, Vol 4, Iss 1, Pp 14-27 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
2079-4983 |
| DOI: |
10.3390/jfb4010014 |
| Popis: |
The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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