Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation
| Autor: | ALANA F. PIRES, GABRIELA F.O. MARQUES, NYLANE M.N. DE ALENCAR, MARIA G.Q. MARTINS, MAYARA T.L. DA SILVA, KYRIA S. DO NASCIMENTO, BENILDO S. CAVADA, ANA MARIA S. ASSREUY |
|---|---|
| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 91, Iss 2 |
| Druh dokumentu: | article |
| ISSN: | 0001-3765 1678-2690 |
| DOI: | 10.1590/0001-3765201920180991 |
| Popis: | Abstract: Dalbergieae tribe lectins, possessing binding affinity for galactose and mannose, present inflammatory and nociceptive effects, while those for N-acetylglucosamine are anti-inflammatory. Since the anti-inflammatory effect of the seed lectin of L. araripensis (LAL) had been already demonstrated in mice, this effect was presently evaluated in rat models of acute inflammation. LAL (0.01-1 mg/kg) was administered by intravenous (i.v.) route in male Wistar rats 30 min before paw edema induction by dextran or carrageenan, and peritonitis by carrageenan. LAL (1 mg/kg) was incubated with N-acetylglucosamine for allowing lectin-sugar interactions before injection into animals. LAL toxicity was evaluated by the parameters: body mass, organs weight, stomach macroscopy, hematological and biochemical dosage. Statistical analysis was performed by ANOVA and Bonferroni’s test (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|