Bone-marrow mononuclear cells and acellular human amniotic membrane improve global cardiac function without inhibition of the NLRP3 Inflammasome in a rat model of heart failure
| Autor: | ALINE L. TAKEJIMA, PAULO ANDRÉ B. MACHADO-JÚNIOR, GUSTAVO G. BLUME, ROSSANA BAGGIO SIMEONI, JULIO CESAR FRANCISCO, MURILO S. TONIAL, LUIS FELIPE B. MARQUEZE, LUCIA NORONHA, MARCIA OLANDOSKI, ELTYEB ABDELWAHID, KATHERINE A.T. DE CARVALHO, RICARDO A. PINHO, LUIZ CÉSAR GUARITA-SOUZA |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 96, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765202420230053 |
| Popis: | Abstract Recent studies have suggested that therapies with stem cells and amniotic membrane can modulate the inflammation following an ischemic injury in the heart. This study evaluated the effects of bone-marrow mononuclear cells (BMMC) and acellular human amniotic membrane (AHAM) on cardiac function and NLRP3 complex in a rat model of heart failure.On the 30th day,the echocardiographic showed improvements on ejection fraction and decreased pathological ventricular remodeling on BMMC and AHAM groups.Oxidative stress analysis was similar between the three groups,and the NLRP3 inflammasome activity were not decreased with the therapeutic use of both BMMC and AHAM,in comparison to the control group. |
| Databáze: | Directory of Open Access Journals |
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