Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring

Autor: Nagif Alata Jimenez, Mauricio Castellano, Emilio M. Santillan, Konstantinos Boulias, Agustín Boan, Luisa F. Arias Padilla, Juan I. Fernandino, Eric L. Greer, Juan P. Tosar, Luisa Cochella, Pablo H. Strobl-Mazzulla
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37427-7
Popis: Anti-folate drugs, such as methotrexate, have been largely prohibited for pregnant women because of the teratogenic effect on their descendant. Here, the authors report a intergenerational mechanism by why paternal methotrexate exposure causes craniofacial defects on their offspring.
Databáze: Directory of Open Access Journals