| Autor: |
Aline Klassen, Andrea Tedesco Faccio, Carolina Raissa Costa Picossi, Priscilla Bento Matos Cruz Derogis, Carlos Eduardo dos Santos Ferreira, Aline Soriano Lopes, Alessandra Sussulini, Elisa Castañeda Santa Cruz, Rafaela Tudela Bastos, Stefanie Caroline Fontoura, Antonio Martins Figueiredo Neto, Marina Franco Maggi Tavares, Maria Cristina Izar, Francisco Antonio Helfenstein Fonseca |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-95455-z |
| Popis: |
Abstract For cardiovascular disease prevention, statins alone or combined with ezetimibe have been recommended to achieve low-density lipoprotein cholesterol targets, but their effects on other lipids are less reported. This study was designed to examine lipid changes in subjects with ST-segment elevation myocardial infarction (STEMI) after two highly effective lipid-lowering therapies. Twenty patients with STEMI were randomized to be treated with rosuvastatin 20 mg QD or simvastatin 40 mg combined with ezetimibe 10 mg QD for 30 days. Fasting blood samples were collected on the first day (D1) and after 30 days (D30). Lipidomic analysis was performed using the Lipidyzer platform. Similar classic lipid profile was obtained in both groups of lipid-lowering therapies. However, differences with the lipidomic analysis were observed between D30 and D1 for most of the analyzed classes. Differences were noted with lipid-lowering therapies for lipids such as FA, LPC, PC, PE, CE, Cer, and SM, notably in patients treated with rosuvastatin. Correlation studies between classic lipid profiles and lipidomic results showed different information. These findings seem relevant, due to the involvement of these lipid classes in crucial mechanisms of atherosclerosis, and may account for residual cardiovascular risk. Randomized clinical trial: ClinicalTrials.gov, NCT02428374, registered on 28/09/2014. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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