Diagnostic performance of lactate dehydrogenase (LDH) isoenzymes levels for the severity of COVID-19

Autor: Ergenc Ilkay, Capar Emre, Erturk Sengel Buket, Bahramzade Gunel, Atalah Fatih, Kocakaya Derya, Karakurt Sait, Haklar Goncagul, Odabasi Zekaver
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Medical Biochemistry, Vol 42, Iss 1, Pp 16-26 (2023)
Druh dokumentu: article
ISSN: 1452-8258
1452-8266
DOI: 10.5937/jomb0-37234
Popis: Background: Lactate dehydrogenase (LDH) levels predict coronavirus disease 2019 (COVID-19) severity. We investigated LDH isoenzyme levels to identify the tissue responsible for serum LDH elevation in patients with COVID-19. Methods: Hospitalised COVID-19 patients with serum LDH levels exceeding the upper reference limit included. LDH isoenzymes were detected quantitatively on agarose gels. The radiological severity of lung involvement on computed tomography was scored as 0-5 for each lobe (total possible score, 0-25). Disease severity was determined using the World Health Organization (WHO) clinical progression scale. Results: In total, 111 patients (mean age, 59.96 ± 16.14), including 43 females (38.7%), were enrolled. The serum levels of total LDH and all five LDH isoenzymes were significantly higher in the severe group. The levels of all LDH isoenzymes excluding LDH5 positively correlated with the WHO score. LDH3 levels correlated with chest computed tomography findings (r2 = 0.267, p = 0.005). On multivariate analysis, LDH3 was an independent risk factor for the deterioration of COVID-19. Conclusions: LDH3 appears to be an independent risk factor for deterioration in patients with COVID-19. LDH elevation in patients with COVID-19 predominantly resulted from lung, liver and muscle damage.
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