Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Autor: Nilah M. Ioannidis, Wei Wang, Nicholas A. Furlotte, David A. Hinds, andMe Research Team, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari, Alice S. Whittemore
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-06149-6
Popis: Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifying five novel genetic loci linked to cSCC susceptibility.
Databáze: Directory of Open Access Journals