Advanced CMR Techniques in Anderson-Fabry Disease: State of the Art

Autor:	Andrea Ponsiglione, Marco De Giorgi, Raffaele Ascione, Carmela Nappi, Luca Sanduzzi, Antonio Pisani, Serena Dell’Aversana, Alberto Cuocolo, Massimo Imbriaco
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	cardiac magnetic resonance Anderson-Fabry disease strain T1 mapping T2 mapping perfusion imaging Medicine (General) R5-920
Zdroj:	Diagnostics, Vol 13, Iss 15, p 2598 (2023)
Druh dokumentu:	article
ISSN:	2075-4418
DOI:	10.3390/diagnostics13152598
Popis:	Anderson-Fabry disease (AFD) is a rare multisystem X-linked lysosomal storage disorder caused by α-galactosidase A enzyme deficiency. Long-term cardiac involvement in AFD results in left ventricular hypertrophy and myocardial fibrosis, inducing several complications, mainly arrhythmias, valvular dysfunction, and coronary artery disease. Cardiac magnetic resonance (CMR) represents the predominant noninvasive imaging modality for the assessment of cardiac involvement in the AFD, being able to comprehensively assess cardiac regional anatomy, ventricular function as well as to provide tissue characterization. This review aims to explore the role of the most advanced CMR techniques, such as myocardial strain, T1 and T2 mapping, perfusion and hybrid imaging, as diagnostic and prognostic biomarkers.
Databáze:	Directory of Open Access Journals
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