Negative Troponin I as a Predictor of Survival in Patients With Coronavirus Disease 2019

Autor: Fergie J. Losiniecki, Jose Lopez, Majd Jazaerly, Kristina Menchaca, Vivek Kothari, Brendon Cornett, Christopher N. Ochner, Robert Chait
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 45, Iss , Pp 101196- (2023)
Druh dokumentu: article
ISSN: 2352-9067
DOI: 10.1016/j.ijcha.2023.101196
Popis: Background: Despite a large amount of evidence evaluating elevated troponin I levels and adverse clinical outcomes, little is known about the role of a normal (negative) troponin I during the first 24 h of admission for risk stratification in patients with Coronavirus Disease 2019 (COVID-19). This study aims to evaluate the utility and negative predictive value of a serum troponin I level to predict in-hospital mortality. Methods: We retrospectively analyzed all adult patients (>18 years of age) with COVID-19 admitted to an HCA Healthcare facility between March 2020 and March 2021 who had a troponin I level drawn at admission. Patients were initially stratified into two groups based on their cardiac troponin I value in the first 24 h of admission (elevated vs negative). Results: A total of 65,580 patients were included in the final analysis. A negative troponin I value was associated with lesser odds of death during admission (OR = 0.32, 95 % CI 0.31–0.34, p
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