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Background and aims: Body adiposity index (BAI) and conicity index have been known as useful measures in predicting cardio-metabolic diseases. This study aimed to evaluate the predictive potential of BAI and conicity index for the risk of metabolic syndrome (MetS) in comparison with body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR). Methods: In this cross-sectional study, 174 adults (87 with MetS and 87 healthy individuals) were recruited from a medical weight loss center. Anthropometric parameters, systolic and diastolic blood pressures (SDP and DBP), lipid profile, and fasting blood sugar (FBS) were measured. Results: All anthropometric parameters were significantly higher in subjects with MetS than in healthy subjects. Both in MetS and healthy subjects, females had significantly higher BAI and BMI than males. In the fully adjusted model, the odds of MetS increased for each unit increase in BAI by 27 % (p = 0.001), in BMI by 33 % (p = 0.001), in WC by 13 % (p |