| Autor: |
Lena Giralt, Marc Figueras-Roca, Beatriz De Luis Eguileor, Barbara Romero, Javier Zarranz-Ventura, Socorro Alforja, Francisca Santiago, Jennifer Bolaños, Francisco Lozano, Marina Dotti-Boada, Anna Sala-Puigdollers, Paula Dura, Jordi Izquierdo-Serra, Oliver Valero, Alfredo Adan, Alex Fonollosa, Blanca Molins |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2024.1330913 |
| Popis: |
PurposeTo determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters.MethodsCross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters.ResultsPatients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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