Green and Efficient Synthesis of Dihydropyrimidinone Analogues via Hpa-Clay Catalyzed Biginelli Reaction
| Autor: | Nuzhat Rehman, Ayaz Mahmood Dar, Raja Feroz Ahmad Haji, Sharief-ud-din Khan, Deepak Pareek, Saleem Farooq, Bashir Ahmad Dar |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 19, Iss 1, Pp 76-83 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1857-1727 2345-1688 |
| DOI: | 10.19261/cjm.2024.1135 |
| Popis: | This study introduces an environmentally sustainable approach for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs), via the Biginelli reaction. A heterogeneous catalyst, Heteropolyacid-Clay (HPA-Clay), is developed by immobilizing H5PV2W10O40 on Montmorillonite KSF clay. The catalyst exhibits enhanced stability and catalytic efficiency, confirmed through X-ray powder diffraction and scanning electron microscopy. Utilizing a one-pot multi-component strategy under solvent-free conditions, various aldehydes, urea or thiourea, and ethylacetoacetate generate DHPMs with excellent yields and reduced reaction times. Catalysed by 2 mol% HPA-Clay, the process aligns with green chemistry principles, emphasizing cost-efficiency, environmental sustainability, and recyclability. The catalyst demonstrates consistent activity over multiple cycles, highlighting its potential for advancing Biginelli reactions. |
| Databáze: | Directory of Open Access Journals |
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