Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601

Autor:	Cangzhu Sun, Yura Ha, Xin Liu, Nan Wang, Xiao-Yuan Lian, Zhizhen Zhang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	marine fungus Aspergillus sp. SY2601 indolyl diketopiperazine aspyrone analogue putative meroterpenoid antimicrobial activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 2, p 459 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29020459
Popis:	Fungi are important resource for the discovery of novel bioactive natural products. This study investigated the metabolites produced by Mariana-Trench-associated fungus Aspergillus sp. SY2601 in EY liquid and rice solid media, resulting in the isolation and structure determination of 28 metabolites, including five new compounds, asperindopiperazines A–C (1–3), 5-methoxy-8,9-dihydroxy-8,9-deoxyaspyrone (21), and 12S-aspertetranone D (26). Structures of the new compounds were elucidated based on extensive NMR spectral analyses, HRESIMS data, optical rotation, ECD, and 13C NMR calculations. The new compound 12S-aspertetranone D (26) exhibited antibacterial activity against both methicillin-resistant Staphylococcus aureus and Escherichia coli with MIC values of 3.75 and 5 μg/mL, respectively.
Databáze:	Directory of Open Access Journals
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