| Autor: |
Priya R. Kadam, Yadav D. Bodke, Mamatha D. Naik, O. Nagaraja, B. Manjunatha |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 4, Iss , Pp 100303- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2022.100303 |
| Popis: |
An efficient and convenient method has been outlined for the synthesis of 3-[(1,3-benzothiazol-2-ylsulfanyl)(phenyl)methyl]-2H-chromen-4-ol derivatives via a one-pot three-component Knoevenagel condensation reaction between 4-hydroxycoumarin, substituted aldehyde, and 2-mercapto benzothiazole in the presence of 10 mol% L-proline as an efficient catalyst in ethanol. The structure of all the newly synthesized chromone derivatives was confirmed by different spectroscopic techniques like IR, 1H NMR, 13C NMR, and LC-MS. Further, all the derivatives were screened for their biological activities such as anti-mycobacterial activity, in vitro antioxidant activity, anticancer activity, and molecular docking studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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