Phenotypic and Molecular-Genetic Analysis of Genetically Modified Toxigenic Vibrio cholerae El Tor Strain 301, Isolated in 2011 in Russia

Autor: A. V. Shashkova, D. A. Agafonov, A. V. Cherkasov, S. P. Zadnova, N. I. Smirnova
Jazyk: ruština
Rok vydání: 2012
Předmět:
Zdroj: Проблемы особо опасных инфекций, Vol 0, Iss 4(114), Pp 61-64 (2012)
Druh dokumentu: article
ISSN: 0370-1069
2658-719X
DOI: 10.21055/0370-1069-2012-4-61-64
Popis: The phenotypic and molecular-genetic analysis of Vibrio cholerae O1 El Tor Inaba strain 301, isolated in 2011 from sea water in recreation zone in Taganrog, demonstrated this isolate to be a genetic variant of El Tor cholera causative agent. Its genome was shown to carry a hybrid prophage, containing gene ctxB of classical type and gene rstR of El Tor type, as well as altered pathogenicity island VPI-1 and pandemicity island VSP-II. This strain produced much more cholera toxin (0,12 mcg/ml) than typical strains of this causative agent.
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