| Autor: |
CHEN Qingxin;CHU Taiwei |
| Jazyk: |
čínština |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Isotopes, Vol 34, Iss 4 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1000-7512 |
| DOI: |
10.7538/tws.2020.youxian.010 |
| Popis: |
In order to develop an ideal 99Tcm-labeled glucose metabolism imaging agent, MAMA-conjugated azadibenzocyclooctyne derivative and four 2-azido glucose derivatives were synthesized. Two potential candidates (N3-DG-1 and N3-DG-2) were selected according to the in vitro kinetic study experiment. The 2-azido glucose derivatives were pretargeted in mice bearing S180 tumor, then 99Tcm-labeled MAMA-azadibenzocyclooctyne derivative was administrated to accomplish the in vivo copper-free click reaction and imaging of glucose metabolism. The biodistribution results showed that the tumor/blood and tumor/muscle ratios of N3-DG-2 were higher than those of N3-DG-1, indicating the combination of 99Tcm-labeled MAMA-azadibenzocyclooctyne derivative and N3-DG-2 was more suitable for glucose metabolism imaging. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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