DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies

Autor:	Ola Rominiyi, Spencer J. Collis
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	chemotherapy DNA damage response glioblastoma radiotherapy synthetic lethality tumour‐treating fields Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular Oncology, Vol 16, Iss 1, Pp 11-41 (2022)
Druh dokumentu:	article
ISSN:	1878-0261 1574-7891
DOI:	10.1002/1878-0261.13020
Popis:	Glioblastoma is the most frequently diagnosed type of primary brain tumour in adults. These aggressive tumours are characterised by inherent treatment resistance and disease progression, contributing to ~ 190 000 brain tumour‐related deaths globally each year. Current therapeutic interventions consist of surgical resection followed by radiotherapy and temozolomide chemotherapy, but average survival is typically around 1 year, with
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b90731c3ae5d42deaae24366486fdb96 Zobrazit plný text záznamu Plný text View record in DOAJ