| Autor: |
Samah Said Elbasateeny, Mahmoud Abdou Yassin, Mohamed Mahmoud Mokhtar, Adel Mohamed Ismail, Huda Fathy Ebian, Samia Hussein, Sherin Attia Shazly, Mai Mohammed Abdelwabab |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Breast Cancer, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2090-3189 |
| DOI: |
10.1155/2022/8096764 |
| Popis: |
Background. Triple negative breast cancer (TNBC) is a biologically separate entity of breast cancer that cannot get benefits from targeted or endocrine therapy. Objective. To assess the expression of MALAT1 and BACH1, as well as monocyte-myeloid-derived suppressor cell (Mo-MDSC) levels and circulating tumor cell (CTC) count in TNBC to correlate these markers with the clinic-pathological criteria of TNCB patients and to evaluate their roles as predictive markers for selection of the patients that can be operated by oncoplastic conserving breast surgery. Methods. Eighty-eight TNBC were managed by modified doughnut breast oncoplastic surgery in early stages and by modified radical mastectomy for patients with late stages unsuitable for breast-conserving. All were examined for MALAT1 and BACH1 expression by immunohistochemistry and RT-PCR as well as Mo-MDSC levels and CTCs. Results. MALAT1 and BACH1 expressions are correlated with the larger size, lymph node, distance metastasis, and TNM staging (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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