Insulin resistance phenotype is associated with vascular risk phenotype at the end of the second decade of life: a population-based study

Autor: Janaina Maiana Abreu Barbosa, Antônio Augusto Moura da Silva, Rosangela Fernandes Lucena Batista, Bernadete Jorge Leal Salgado, Joelma Ximenes Prado Teixeira Nascimento, Vanda Maria Ferreira Simões, Maria Jacqueline Silva Ribeiro, Marco Antonio Barbieri, Alexandre Archanjo Ferraro, Cecilia Claudia Costa Ribeiro
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1475-2840
DOI: 10.1186/s12933-022-01724-0
Popis: Abstract We hypothesize that early events of diabetes and cardiovascular disease continuums would be ongoing and associated in adolescents. We investigated the association between the Insulin Resistance Phenotype and the Vascular Risk Phenotype at the end of the second decade of life and indirect pathways from social vulnerability, alcohol consumption, and body fat mass. It is a population-based study in the RPS cohort of 18–19 years (n = 2,515), São Luís, Brazil. The theoretical model analyzed the association between Insulin Resistance Phenotype and Vascular Risk Phenotype by sex, using structural equation modeling (SEM). The Insulin Resistance Phenotype was a latent variable deduced from the correlations of Triglyceride to HDL ratio, Triglyceride Glycemic index, and VLDL; the Vascular Risk Phenotype was deduced from Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Wave Velocity. The Insulin Resistance Phenotype was directly associated with the Vascular Risk Phenotype in males (standardized coefficient SC = 0.183; p
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