| Autor: |
Mariana Sousa Silva, Cláudio Henrique Lima Rocha, Arménio Aguiar dos Santos, Moisés Tolentino Bento da Silva |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Revista Portuguesa de Cardiologia, Vol 43, Iss 11, Pp 613-620 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
0870-2551 |
| DOI: |
10.1016/j.repc.2024.03.006 |
| Popis: |
Introduction and objective: Cisplatin induces many collateral effects such as gastrointestinal disorders, nephrotoxicity, and dysautonomia. Recently our group showed that cisplatin treatment induces gastric emptying delay and that physical exercise and treatment with pyridostigmine prevent this change. In the current study, we investigated the role of moderate exercise on cardiac activity and autonomic balance in rats treated with cisplatin. Methods: Male Wistar rats were divided into saline, cisplatin, exercise, and exercise+cisplatin groups. Cardiac and autonomic disorders were induced by (cisplatin – 3 mg/kg, i.p. once a week/per 5 weeks). Exercise consists of swimming (1 hour per day/5× day per week/per 5 weeks without overload). Forty-eight hours after the last session of the training or treatment, we assessed the cardiac activity and HRV via electrocardiogram analysis in DII derivation. Results: Cisplatin increase (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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