Preconditioning rats with three lipid emulsions prior to acute lung injury affects cytokine production and cell apoptosis in the lung and liver

Autor:	Li-Mi Huang, Qingqing Hu, Xiaoxia Huang, Yan Qian, Xin-He Lai
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Acute lung injury Parenteral nutrition Cytokine Apoptosis Liver function Nutritional diseases. Deficiency diseases RC620-627
Zdroj:	Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-9 (2020)
Druh dokumentu:	article
ISSN:	1476-511X
DOI:	10.1186/s12944-019-1137-x
Popis:	Abstract Background Critically ill patients are at higher risk having acute lung injury (ALI) and more often in need of parenteral nutrition. We sought to study whether preconditioning with representative of lipid emulsions for one week could benefit rats from ALI. Methods Using a lipopolysaccharide (LPS)-induced ALI rat model and techniques such as polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Results PGE2 production in the serum was highest in the LPS group, followed with Intralipid group, and the PGE2 level of these two groups was significantly (P
Databáze:	Directory of Open Access Journals
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