Effects of 5-aminolevulinic acid on the inflammatory responses and antioxidative capacity in broiler chickens challenged with lipopolysaccharide

Autor: Jiang Chen, Huakang Wang, Zhengke Wu, Hongxia Gu, Chong Li, Shaolong Wang, Guohua Liu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Animal, Vol 16, Iss 7, Pp 100575- (2022)
Druh dokumentu: article
ISSN: 1751-7311
DOI: 10.1016/j.animal.2022.100575
Popis: 5-Aminolevulinic acid (5-ALA) is an intermediate in haem biosynthesis and has anti-apoptotic, anti-inflammatory, antioxidant, and other pharmacological effects. This study aimed to investigate the effect of dietary supplementation with 5-ALA on growth performance, antioxidant capacity, and inflammatory response of the lipopolysaccharide (LPS)-challenged broiler chickens. The experiment was designed as a 2 × 2 factorial arrangement with dietary 5-ALA (0 or 60 mg/kg) and LPS (injection of saline or 0.5 mg/kg BW) levels as treatments. A total of 240 one-day-old Arbor Acres broilers were distributed into four treatments consisting of six replicates of 10 birds. All the experimental broilers were intraperitoneally injected with LPS or sterile saline at 16, 18, and 20 days of age. Our results showed that dietary 5-ALA supplementation reduced (P
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