| Autor: |
Awad Elsid Osman, Sahar Alharbi, Atif Ali Ahmed, Asim Ali Elbagir |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Asian Journal of Urology, Vol 11, Iss 1, Pp 26-32 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2214-3882 |
| DOI: |
10.1016/j.ajur.2022.03.012 |
| Popis: |
Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically related. Methods: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction assay. Results: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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