| Autor: |
Asha R Kallianpur, Peilin Jia, Ronald J Ellis, Zhongming Zhao, Cinnamon Bloss, Wanqing Wen, Christina M Marra, Todd Hulgan, David M Simpson, Susan Morgello, Justin C McArthur, David B Clifford, Ann C Collier, Benjamin B Gelman, J Allen McCutchan, Donald Franklin, David C Samuels, Debralee Rosario, Emily Holzinger, Deborah G Murdock, Scott Letendre, Igor Grant, CHARTER Study Group |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 8, p e103123 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0103123 |
| Popis: |
HIV sensory neuropathy and distal neuropathic pain (DNP) are common, disabling complications associated with combination antiretroviral therapy (cART). We previously associated iron-regulatory genetic polymorphisms with a reduced risk of HIV sensory neuropathy during more neurotoxic types of cART. We here evaluated the impact of polymorphisms in 19 iron-regulatory genes on DNP in 560 HIV-infected subjects from a prospective, observational study, who underwent neurological examinations to ascertain peripheral neuropathy and structured interviews to ascertain DNP. Genotype-DNP associations were explored by logistic regression and permutation-based analytical methods. Among 559 evaluable subjects, 331 (59%) developed HIV-SN, and 168 (30%) reported DNP. Fifteen polymorphisms in 8 genes (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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