PD-L1NEUT, Foxp3Treg, and NLR as New Prognostic Marker with Low Survival Benefits Value in Hepatocellular Carcinoma
| Autor: | Lin Zhou PhD, Jing Wang MD, Shao-cheng Lyu PhD, Li-chao Pan PhD, Xian-jie Shi PhD, Guo-sheng Du PhD, Qiang He PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 20 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1533-0338 15330338 |
| DOI: | 10.1177/15330338211045820 |
| Popis: | Background: This presented study was aimed to evaluate the diagnostic and prognostic value of PD-L1 + Neutrophils (PD-L1 + NEUT) and neutrophil to lymphocyte ratio (NLR) based on our previous experience of Foxp3 + Treg in transplantation. Methods: the NLR cutoff value of 1.79 was used to include 136 cases from the 204 patients with hepatocellular carcinoma (HCC) confirmed by clinical pathology, which were divided into highly-moderately and poorly differentiated HCC groups. The expressions of PD-L1 + NEUT and Foxp3 + Treg in peripheral blood and cancer tissue were detected with flow cytometry, meanwhile, PD-L1 and Foxp3 expressed in carcinoma and para-carcinoma tissues were marked by immunohistochemistry. Survival rates, including overall survival and disease-free survival, were calculated by the Kaplan–Meier curve and evaluated with the log-rank test. Finally, Cox risk regression model was used to analyze the independent risk factors for prognostic survival. Results: The level of PD-L1 + NEUT, Foxp3 + Treg, and NLR in peripheral blood of patients with poorly differentiated HCC were significantly increased (all P |
| Databáze: | Directory of Open Access Journals |
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