Additive and Dominance Genome-Wide Association Studies Reveal the Genetic Basis of Heterosis Related to Growth Traits of Duhua Hybrid Pigs

Autor: Jiakun Qiao, Kebiao Li, Na Miao, Fangjun Xu, Pingping Han, Xiangyu Dai, Omnia Fathy Abdelkarim, Mengjin Zhu, Yunxiang Zhao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Animals, Vol 14, Iss 13, p 1944 (2024)
Druh dokumentu: article
ISSN: 2076-2615
DOI: 10.3390/ani14131944
Popis: Heterosis has been extensively used for pig genetic breeding and production, but the genetic basis of heterosis remains largely elusive. Crossbreeding between commercial and native breeds provides a good model to parse the genetic basis of heterosis. This study uses Duhua hybrid pigs, a crossbreed of Duroc and Liangguang small spotted pigs, as materials to explore the genetic basis underlying heterosis related to growth traits at the genomic level. The mid-parent heterosis (MPH) analysis showed heterosis of this Duhua offspring on growth traits. In this study, we examined the impact of additive and dominance effects on 100 AGE (age adjusted to 100 kg) and 100 BF (backfat thickness adjusted to 100 kg) of Duhua hybrid pigs. Meanwhile, we successfully identified SNPs associated with growth traits through both additive and dominance GWASs (genome-wide association studies). These findings will facilitate the subsequent in-depth studies of heterosis in the growth traits of Duhua pigs.
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