Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus

Autor: Chang-hao XIE, Xiang LIAO, Ling-yun SUN, Guo-min DENG
Jazyk: English<br />Chinese
Rok vydání: 2014
Předmět:
Zdroj: Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 14, Iss 9, Pp 769-774 (2014)
Druh dokumentu: article
ISSN: 1672-6731
Popis: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, which is characterized by high levels of autoantibodies and multisystem damage. Neuropsychiatric SLE (NPSLE) involves both the central and peripheral nervous systems, which is one major cause of death in SLE patients. Pathogenesis of NPSLE is complicated. Currently it is known that there are two mechanisms to be involved in NPSLE: one is cerebrovascular injury mediated by immune complex containing autoantibodies, and the other is brain tissue damage induced by inflammatory mediators originated from autoimmunity. doi: 10.3969/j.issn.1672-6731.2014.09.006
Databáze: Directory of Open Access Journals