Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome
| Autor: | Minh Lam, YooJin Lee, Min Deng, Andrew H. Hsia, Kelly A. Morrissey, Chunlin Yan, Kashif Azzizudin, Nancy L. Oleinick, Thomas S. McCormick, Kevin D. Cooper, Elma D. Baron |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Advances in Hematology, Vol 2010 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1687-9104 1687-9112 |
| DOI: | 10.1155/2010/896161 |
| Popis: | Our current focus on the effects of Photodynamic Therapy (PDT) using silicon phthalocyanine Pc 4 photosensitizer on malignant T lymphocytes arose due to preclinical observations that Jurkat cells, common surrogate for human T cell lymphoma, were more sensitive to Pc 4-PDT-induced killing than epidermoid carcinoma A431 cells. Mycosis fungoides (MF) as well as Sezary syndrome (SS) are variants of cutaneous T-cell lymphoma (CTCL) in which malignant T-cells invade the epidermis. In this study, we investigated the cytotoxicity of Pc 4-PDT in peripheral blood cells obtained from patients with SS and in skin biopsies of patients with MF. Our data suggest that Pc 4-PDT preferentially induces apoptosis of CD4+CD7− malignant T-lymphocytes in the blood relative to CD11b+ monocytes and nonmalignant T-cells. In vivo Pc 4-PDT of MF skin also photodamages the antiapoptotic protein Bcl-2. |
| Databáze: | Directory of Open Access Journals |
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