| Autor: |
Jacqueline Batista Sousa, Renata Margarida Etchebehere, Dulciene Maria de Magalhães Queiroz, Fernanda Machado Fonseca, Bianca Bontempi Batista, Iracema Saldanha Junqueira, Sílvia Maria Perrone Camilo, Adriana Gonçalves de Oliveira |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 61, Iss 0 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1678-9946 |
| DOI: |
10.1590/s1678-9946201961007 |
| Popis: |
ABSTRACT Trypanosoma cruzi and Helicobacter pylori (HP) are pathogens that cause chronic diseases and have been associated with hypergastrinemia. The aim of this study was to evaluate the fasting gastrin levels in patients with different clinical forms of Chagas disease (CD), coinfected or not by HP. The enrolled individuals were outpatients attending at the university hospital. HP infection was assessed by serology and 13 C-urea breath test. Fasting serum gastrin concentration was measured by chemiluminescence assay. Gastric endoscopic and histological features were also evaluated. Associations between CD and serum gastrin level were evaluated in a logistical model, adjusting for age, gender and HP status. A total of 113 patients were evaluated (45 with Chagas disease and 68 controls). In the multivariate analysis, increasing serum gastrin levels (OR= 1.02; 95% CI= 1.01-1.12), increasing age (OR= 1.05; 95% CI= 1.02 - 1.09) and HP-positive status (OR = 2.88; 95% CI = 1.10 - 7.51) remained independently associated with CD. The serum gastrin levels were significantly higher in the group of patients with the cardiodigestive form ( P = 0.03) as well as with digestive form ( P = |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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