Green one-pot, four-component synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives using amino-functionalized nanoporous silica SBA-15 under solvent-free conditions

Autor: Ziarani Ghodsi Mohammadi, Rahimifard Mahshid, Nouri Fatemeh, Badiei Alireza
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Journal of the Serbian Chemical Society, Vol 80, Iss 10, Pp 1265-1272 (2015)
Druh dokumentu: article
ISSN: 0352-5139
1820-7421
DOI: 10.2298/JSC140930045M
Popis: Propylamine functionalized nanoporous silica (SBA-Pr-NH2) has been used as an efficient heterogeneous solid basic nanoreactor in the synthesis of 6'-amino-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one derivatives 5 through one-pot, four component condensation of isatin derivatives 1, activated methylene reagents 2, hydrazine hydrate 3 and β-keto esters 4 under solvent free conditions at room temperature
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