Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor

Autor: Nariman Shahid, Alia Erum, Muhammad Zaman, Ume Ruqia Tulain, Qurat-ul-ain Shoaib, Nadia Shamshad Malik, Rizwana Kausar, Ayesha Rashid, Umaira Rehman
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Designed Monomers and Polymers, Vol 25, Iss 1, Pp 55-63 (2022)
Druh dokumentu: article
ISSN: 1385-772X
1568-5551
15685551
DOI: 10.1080/15685551.2022.2054117
Popis: The aim of this contemporary work was to formulate a controlled release mucoadhesive nanoparticle formulation for enhancing the oral bioavailability of Ticagrelor (TG), a BCS class IV drug, having low oral bioavailability of about 36%. The nanoparticles can act as efficient carriers for hydrophobic drugs, due to having high surface area and hence can improve their aqueous solubility due to their hydrophilic nature. The nanoparticles (NPs) of TG were formulated using chitosan (CH) as polymer and sodium tripolyphosphate (TPP) as cross-linker, by ionic gelation technique with varying concentrations of polymer with respect to TG and TPP. Characterization of prepared nanoparticles was carried out to assess zeta potential, size, shape, entrapment efficiency (EE) and loading capacity (LC), using zeta sizer, surface morphology and chemical compatibility analysis. Drug release was observed using UV-Spectrophotometer. By increasing concentration of CH the desired size of particles (106.9 nm), zeta potential (22.6 mv) and poly dispersity index (0.364) was achieved. In vitro profiles showed a controlled and prolonged release of TG in both lower pH-1.2 and neutral pH-7.4 mediums, with effective protection of entrapped TG in simulated gastric conditions. X-ray diffraction patterns (XRD) showed the crystalline nature of formed NPs. Hence, this effort showed that hydrophobic drugs can be effectively encapsulated in nanoparticulate systems to enhance their solubility and stability, ultimately improving their bioavailability and effectiveness with better patient compliance by reducing dosing frequencies as well.
Databáze: Directory of Open Access Journals
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