Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress

Autor: Stefan Rudloff, Mathilde Janot, Stephane Rodriguez, Kevin Dessalle, Willi Jahnen-Dechent, Uyen Huynh-Do
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20832-7
Popis: Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis.
Databáze: Directory of Open Access Journals