Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study
| Autor: | Sunita Lamichaney, Priyam Goswami, Monigopa Das, Pranjal Kumar Dutta, Tanvee Yusuf |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 18, Iss 11, Pp 21-24 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2024/67325.20315 |
| Popis: | Introduction: Sepsis is a leading cause of morbidity and mortality worldwide, and the Sequential Organ Failure Assessment (SOFA) score is used as a key criterion in diagnosing the sepsis syndrome. Recent studies have also suggested that vitamin D is an important mediator in the immune system and plays an inhibitory role in sepsis. Aim: To assess serum vitamin D levels in patients with sepsis and to investigate the correlation between vitamin D levels and the SOFA score, as well as the outcomes of sepsis. Materials and Methods: This was a hospital-based cross-sectional study carried out on 91 patients diagnosed with sepsis. The SOFA score was calculated within 24 hours of admission and again at 72 hours; however, only the SOFA score obtained on admission (within 24 hours) was used to assess disease severity and to compare with vitamin D levels. Vitamin D assessment was conducted using a competitive immunoassay in the VITROS 5600 fully automated integrated assay system. Pearson’s correlation (r) was used to measure the association between variables. Results: The mean age of the study population was 57.34±16.55 years, with a male to female ratio of 1.17:1. A significant increase in vitamin D deficiency was noted in patients with a SOFA score above 10. There was a negative correlation between serum vitamin D levels and the SOFA score within 24 hours after admission, which was statistically significant (p-value |
| Databáze: | Directory of Open Access Journals |
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