| Autor: |
Kahoko Nishikawa, Masahiro Hashimoto, Yoshiyuki Itoh, Sadayuki Hiroi, Akihiko Kusai, Fumihiko Hirata, Toshihisa Sakamoto, Keiichi Iwaya |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
FEBS Open Bio, Vol 4, Iss C, Pp 179-184 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2211-5463 |
| DOI: |
10.1016/j.fob.2014.02.005 |
| Popis: |
Matrix-assisted laser desorption/ionisation spiral orbit-type time-of-flight mass spectrometry (MALDI-SpiralTOF) can analyse lipid profiles and characterise lipid structure. Imaging mass spectrometry (IMS) also provides distribution maps of selected m/z values. Here, we investigated triacylglycerol (TG) structure and distribution using these technologies to estimate mouse fatty liver. The distribution and intensity of the most intense mass spectrum ion was indicated by IMS at m/z 881.7 (52:2). Analysis using MS/MS showed a structural change between liver TG and dietary TG. These findings suggest that MALDI-SpiralTOF is a powerful tool for clinical screening and estimating fatty liver. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text