First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
| Autor: | Vivaldo Gomes da Costa, Marielena Vogel Saivish, Priscila Gomes de Oliveira, Abelardo Silva-Júnior, Marcos Lázaro Moreli, Ricardo Henrique Krüger |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2045-2322 17071844 |
| DOI: | 10.1038/s41598-021-92183-2 |
| Popis: | Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil. |
| Databáze: | Directory of Open Access Journals |
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