Effects of doxycycline treatment on hematological and blood biochemical parameters in dogs naturally infected with Ehrlichia canis
| Autor: | Elena Atanaskova Petrov, Igor Ulcar, Irena Celeska, Ksenija Ilievska, Pandorce Spasovska Trenkovska, Todor Novakov, Kiril Krstevski, Toni Dovenski, Jovana Stefanovska |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Macedonian Veterinary Review, Vol 41, Iss 1, Pp 99-105 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1409-7621 1857-7415 |
| DOI: | 10.2478/macvetrev-2018-0011 |
| Popis: | Ehrlichia canis, the etiologic agent of canine monocytic ehrlichiosis (CME), is mainly transmitted by the brown dog tick Rhipicephalus sanguineus. Clinical signs of the disease can be various, depending on the stage of the disease. Typical changes in hematological and blood biochemical parameters are: severe thrombocytopenia, mild to marked non regenerative anaemia and hypoalbuminemia. In order to present the effects of the treatment protocol on several hematological and biochemistry parameters, 34 Ehrlichia canis positive dogs were compared before and after treatment with doxycycline 10mg/kg/day, in duration of four weeks. Besides the clinical sings and laboratory findings, diagnosis was confirmed by antibody tests (Bionote, Korea, AGROLABO S.p.A., Italy). The most common clinical sings were depression, lethargy, pyrexia, vomiting and anorexia. Hematological analyses were performed on the automatic hematology analyzer Exigo ЕоѕVet (Sweden), while biochemistry analyses (alanine aminotransferase, aspartate aminotransferase, urea, creatinine, albumin, total protein, globulin and alkaline phosphatase) were performed using the automatic analyzer ChemWell 2910 (Awareness Technology, INC, USA). Statistically significant difference (p |
| Databáze: | Directory of Open Access Journals |
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