Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia
| Autor: | Kamgno J., Boussinesq M. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Parasite, Vol 9, Iss 1, Pp 59-63 (2002) |
| Druh dokumentu: | article |
| ISSN: | 1252-607X 1776-1042 |
| DOI: | 10.1051/parasite/200209159 |
| Popis: | The problem of Loa encephalopathy, which may occur after ivermectin treatment of patients harbouring high Loa microfilarial loads, might be solved if one could find a treatment regimen bringing about a significant but progressive decrease in the Loa microfilaraemia. A trial was performed in Central Cameroon, whose aim was to follow up for 1 0 months, and to compare the changes in the Loa microfilarial loads in two groups of patients, one treated with a single dose (600 mg) of albendazole (Alben®, SmithKline Beecham) given with fatty food, and the other treated with mebendazole (100 mg, twice a day, generic tablets) at a fasting state. The microfilarial loads remained stable in the mebendazole group, whereas a significant decrease in microfilaraemia was recorded in the albendazole group (initial median load: 230 microfilariae per 50 μl; median load ten months after: 84 microfilariae per 50 μl). This should encourage further trials to evaluate the effects and the safely of two- or three-day albendazole regimens in patients infected with Loa loa. |
| Databáze: | Directory of Open Access Journals |
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