| Autor: |
Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-13722-0 |
| Popis: |
GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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