| Autor: |
Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Zachary Mazanek, Naveen Mohideen, Albert Y. Lau, Edward H. Egelman, Jungsan Sohn |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-021-23045-8 |
| Popis: |
AIM2-ASC inflammasomes are filamentous signalling platforms that play a central role in host innate defence. Here, the authors present the filament cryo-EM structure of the inflammasome receptor AIM2, which is very similar to the adaptor ASC filament structure. By employing Rosetta and Molecular Dynamics simulations the authors provide further insights into the directionality and recognition mechanisms of the individual AIM2 and ASC filaments, which is further validated with biochemical and cellular experiments. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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