| Autor: |
Arianna Rubin Means, Kristjana Hrönn Ásbjörnsdóttir, Katherine C. Sharrock, Sean R. Galagan, Kumudha Aruldas, Euripide Avokpaho, Félicien Chabi, Katherine E. Halliday, Parfait Houngbegnon, Gideon John Israel, Saravanakumar Puthupalayam Kaliappan, David Kennedy, Hugo Legge, William E. Oswald, Gokila Palanisamy, Elliott Rogers, Joseph Timothy, Emily Pearman, Rohan Michael Ramesh, James Simwanza, Jasmine Farzana Sheik-Abdullah, Mariyam Sheikh, Comlanvi Innocent Togbevi, Stefan Witek-McManus, Rachel L. Pullan, Robin Bailey, Khumbo Kalua, Moudachirou Ibikounlé, Adrian J. F. Luty, Sitara S. R. Ajjampur, Judd L. Walson |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Infectious Diseases of Poverty, Vol 13, Iss 1, Pp 1-14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2049-9957 |
| DOI: |
10.1186/s40249-024-01241-0 |
| Popis: |
Abstract Background Soil-transmitted helminths (STH) affect approximately 1.5 billion people globally. The current STH control strategy is annual or twice-annual preventive chemotherapy, typically school-based deworming targeting children and women of reproductive age. Mathematical modeling suggests that it may be possible to interrupt STH transmission through high-coverage community-wide mass drug administration (cMDA). DeWorm3 is a cluster randomized trial testing cMDA for prevalence reduction and transmission interruption. The purpose of this study is to describe coverage of cMDA in study clusters over time and correlates of coverage at individual and cluster levels. Methods From 2018–2020, DeWorm3 delivered six rounds of cMDA with 400 mg albendazole at sites in Benin, India, and Malawi. We report coverage, treatment uptake, and directly observed therapy across all rounds. Factors associated with coverage at the cluster level were identified using binomial generalized estimating equations, while factors associated with non-treatment at the individual level were identified using binomial mixed-effects models. Results Coverage was high across all clusters and rounds, exceeding the WHO target of 75% in all sites and across all rounds (78% to 95%); cluster-level coverage tended to increase over time. Younger, unmarried, and migratory adults were more likely to be untreated at all sites; adult males were more likely to be untreated in Benin and Malawi. Among children, girls were more likely to be untreated, as were non-school-attending and migratory children. Higher adult education was associated with greater odds of non-treatment among adults, but lower odds among children in the household. Belonging to a less wealthy or minority language-speaking household was associated with non-treatment among both adults and children. Conclusions It is possible to deliver community-wide MDA with high coverage. Unique individual and community-level factors influence treatment across settings, and these may be addressed through targeted programming. Trial Registration: Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH), NCT03014167. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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