| Autor: |
Vujasinović-Stupar Nada, Milić Nataša, Petrović-Rackov Ljiljana, Prodanović Nenad, Mijailović-Ivković Milena, Grujić Zoran, Buković Stevan, Novković Snežana, Pašalić-Simić Katarina, Petrović Vera, Vukašinović Dragan, Peruničić Gordana |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Srpski Arhiv za Celokupno Lekarstvo, Vol 138, Iss 1-2, Pp 56-61 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
0370-8179 |
| DOI: |
10.2298/SARH1002056V |
| Popis: |
Introduction. Osteoporosis usually affects post-menopausal women. Treatment is individualized and requires an approach that will provide long-term compliance to prevent fractures. Studies conducted so far suggest inadequate compliance and persistence in weekly bisphosphonate treatment (under 43% after a year of treatment). Ibandronate, as a powerful bisphosphonate, has made it possible for the first time to treat osteoporosis with a single tablet per month. Objective. Study of efficacy, safety and tolerance of ibandronate applied once a month in female patients with decreased bone mineral density (BMD). Methods. The prospective study was conducted in 34 centres in Serbia covering the total of 370 women with reduced BMD with ibandronate once a month. Demographic data, risk factors for osteoporosis, mode of diagnosis establishment, previous treatment for osteoporosis and concomitant diseases were investigated. Efficacy of the treatment was evaluated by T-score value after 12 months versus the baseline values. Tolerance of the treatment, compliance and adverse effects were recorded. Results. The sample included 97.5% post-menopausal women, 92.7% with osteoporosis. In 80% of the cases, the diagnosis was established by DXA measurement. In more than 90% of the sample, the level of physical activity was unsatisfactory, and 70% had an accompanying risk factor for osteoporosis in addition to menopause. After 12 months of treatment, 100% compliance was recorded in 84% of the patients and significant reduction (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
