Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction
| Autor: | Alan Rembach, Dominic J. Hare, Monica Lind, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Ashley I. Bush, Colin L. Masters, Blaine R. Roberts |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | International Journal of Alzheimer's Disease, Vol 2013 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2090-8024 2090-0252 |
| DOI: | 10.1155/2013/623241 |
| Popis: | Alzheimer’s disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeostasis of these essential elements, which can impart profound effects on cell viability and neuronal function. We tested the hypothesis that there is a systemic perturbation in Cu compartmentalization in AD, within the brain as well as in the periphery, specifically within erythrocytes. Our results showed that the previously reported decrease in Cu within the human frontal cortex was confined to the soluble (P |
| Databáze: | Directory of Open Access Journals |
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