Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers

Autor: Asma Khalid, Romina Norello, Amanda N. Abraham, Jean-Philippe Tetienne, Timothy J. Karle, Edward W. C. Lui, Kenong Xia, Phong A. Tran, Andrea J. O’Connor, Bruce G. Mann, Richard de Boer, Yanling He, Alan Man Ching Ng, Aleksandra B. Djurisic, Ravi Shukla, Snjezana Tomljenovic-Hanic
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nanomaterials, Vol 9, Iss 10, p 1360 (2019)
Druh dokumentu: article
ISSN: 2079-4991
DOI: 10.3390/nano9101360
Popis: Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial and in-house ball-milled MgO nanoparticles, respectively. As such, the NPs have been successfully integrated into cultured cells and photostable bright in vitro emission from NPs was recorded and analyzed. We expect that numerous biotechnological and medical applications will emerge as this nanomaterial satisfies all criteria for short-term in vivo imaging.
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