Immunohistoochemical evaluation of GATA-3, pAKT and Ki-67 in triple negative breast carcinoma
| Autor: | Gopi Aryal, Sameer Chhetri Aryal, Yurie Soejima, Victoria Sheckler, Yoshinobu Eishi, Motoji Sawabe |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Pathology of Nepal, Vol 7, Iss 2, Pp 1196-1201 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2091-0797 2091-0908 |
| DOI: | 10.3126/jpn.v7i2.18037 |
| Popis: | Background: Triple-negative breast cancers lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor -2. These tumors have been known to be clinically aggressive. We evaluate GATA-3, pAKT and Ki-67 expression in 35 triple negative breast carcinomas.Materials and Methods: A total of 35 triple negative breast carcinomas were included in this study. The histological subtyping was done according to Japanese guidelines for breast cancer.Results: GATA-3 was positive in 60% (21/35) of tumors. High GATA-3 expression was observed in ductal carcinoma in situ. pAKT expression was demonstrated in 85.7 % (30/35) of TNBCs. The levels of expression of GATA-3 and pAKT showed no significant association with nuclear grading. (P=0.761 and P=0.487, respectively). Ki-67 labeling index was positively correlated with nuclear grading (pConclusion: GATA-3 expression has no relation with ER and PR expression and pAKT and GATA-3 are strongly expressed in TNBCs. |
| Databáze: | Directory of Open Access Journals |
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